Achievements研究成果

2025年

  1. The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice
    Katsuma K, Shimada K, Tonai S, Mashiko D, Iida-Norita R, Kaneda Y, Miyata H, Ikawa M.
    Andrology. 2025 Apr 23. doi: 10.1111/andr.70045
     
  2. KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice
    Kitakaze H, Miyata H, Oyama Y, Pan C, Kujime Y, Tsujimura G, Imanaka T, Kuribayashi S, Ueda N, Takezawa K, Fukuhara S, Nonomura N, Ikawa M.
    Reprod Med Biol. 2025 May 27. doi: 10.1002/rmb2.12659
     
  3. Syncytin-1 Is Responsible for the Fusion Between Human Trophoblasts and Endometrial Stromal Cells
    Oike A, Shibata S, Arima T, Okae H.
    Dev Growth Differ. 2025 Jun 12. doi: 10.1111/dgd.70014
     
  4. H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes
    Mei H, Hayashi R, Kozuka C, Kumon M, Koseki H, Inoue A.
    Nat Struct Mol Biol. 2025 June 13. doi.org/10.1038/s41594-025-01573-x
    論文紹介
     
  5. Mouse genome engineering uncovers 18 genes dispensable for male reproduction
    Chang HY, Lu Y, Yamamoto K, Sun J, Shimada K, Hiradate Y, Fujihara Y, Ikawa M.
    Andrology. 2025 Jun 26. doi: 10.1111/andr.70088
     
  6. An ex vivo uterine system captures implantation, embryogenesis, and trophoblast invasion via maternal-embryonic signaling
    Hiraoka T, Aikawa S, Mashiko D, Nakagawa T, Shirai H, Hirota Y, Kimura H, Ikawa M.
    Nat Commun. 2025 Jul 1;16:5755. doi: 10.1038/s41467-025-60610-x
    論文紹介
     

  7. Generation of the Nonintegrated Human Bilaminar Embryo Model (Bilaminoid) from Naïve Pluripotent Stem Cells
    Okubo T, Takashima Y.
    Methods Mol Biol. 2025 Jul 15. doi: 10.1007/7651_2025_652

  8. Development of a sensor-compatible vascular microphysiological system for metabolic monitoring during drug-induced endothelial injury
    Fu Y, Okitsu R, Nashimoto Y, Shinoda Y, Utagawa Y, Yamazaki M, Nakaya K, Ino K, Kaji H.
    Anal Sci. 2025 Jul 17 (Epub). doi: 10.1007/s44211-025-00825-6

  9. Compensation for X-linked Pdha1 silencing by Pdha2 is essential for meiotic double-strand break repair in spermatogenesis
    Pan C, Shimada K, Chang HY, Wang H, Ikawa M.
    Development. 2025 Aug 1. doi: 10.1242/dev.204683

  10. Transcription factor-mediated germ cell induction in rats reveals ETV4 cooperates with germline specifiers
    Oikawa M, Kojima H, Kobayashi H, Iwatsuki K, Saito H, Sanbo M, Nishioka K, Yamaguchi T, Yamamoto T, Kurimoto K, Hirabayashi M, Kobayashi T.
    Stem Cell Reports. 2025 Aug 12. doi: 10.1016/j.stemcr.2025.102599

  11. Germline transmission of cryopreserved mouse spermatogonial stem cells maintained on the International Space Station
    Kanatsu-Shinohara M, Yamamoto T, Shiromoto Y, Morimoto H, Liu T, Yamamori T, Yamasaki T, Shinohara T.
    Stem Cell Reports. 2025 Aug 14 (Epub). doi: 10.1016/j.stemcr.2025.102602

  12. Proximity labeling of axonemal protein CFAP91 identifies EFCAB5 that regulates sperm motility
    Wang H, Shimada K, Pham AH, Oyama Y, Kamoshita M, Kobayashi H, Oura S, Yabuta N, Ikawa M, Miyata H.
    Nat Commun. 2025 Sep 10;16(1):8238. doi: 10.1038/s41467-025-63705-7

  13. GALNTL5 binds GalNAc and is required for migration through the uterotubal junction and sperm-zona pellucida binding
    Noda T, Uriu R, Mashiko D, Shinohara H, Qu Y, Taira A, Matzuk RM, Tahala D, Nakano M, Araki K, Yu Z, Zhang Y, Matzuk MM, Ikawa M.
    Nat Commun. 2025 Sep 17;16(1):8264. doi: 10.1038/s41467-025-63805-4​

  14. In vitro system completely restores oogenesis in congenitally infertile mice
    Yoshida K, Kimura S, Taguchi M, Morimoto H, Kanatsu-Shinohara M, Shinohara T, Obata Y.
    Hum Reprod. 2025 Oct 7; doi:10.1093/humrep/deaf194
     

  15. Sperm and offspring production in a nonobstructive azoospermia mouse model via testicular mRNA delivery using lipid nanoparticles
    Mashiko D, Emori C, Hatanaka Y, Motooka D, Pan C, Kaneda Y, Matzuk MM, Ikawa M.
    Proc Natl Acad Sci U S A. 2025 Oct 21;122(42):e2516573122
    doi: 10.1073/pnas.2516573122. PMID: 41082659
    論文紹介

  16. Formation of a complex between TMEM217 and the sodium-proton exchanger SLC9C1 is crucial for mouse sperm motility and male fertility
    Iida-Norita R, Miyata H, Ninomiya A, Emori C, Kamoshita M, Pan C, Wang H, Ikawa M.
    Proc Natl Acad Sci U S A. 2025 Oct 21;122(42):e2513924122
    doi: 10.1073/pnas.2513924122. PMID: 41091759

  17. CRISPR/Cas9-mediated Genome-editing Reveals 10 Testis-enriched Genes and One Non-testis-enriched Gene are Dispensable for Male Fecundity in Mice
    Qiu Y, Shimada K, Ikawa M.
    Andrology. 2025 Nov 10. doi: 10.1111/andr.70144

  18. SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice
    Mashiko D, Tonai S, Miyata H, Matzuk MM, Ikawa M.
    Elife. 2025 Nov 12. doi: 10.7554/eLife.107494

  19. Control of bioenergetic balance in mouse spermatogonial stem cells by alanine metabolism
    Miyazaki T, Ogonuki N, Kanatsu-Shinohara M, Yamamoto T, Matoba S, Ogura A, Shinohara T.
    Biol Reprod. 2025 Nov 14. doi: 10.1093/biolre/ioaf144

  20. Allogeneic germline stem cell transplantation restores fertility in nonablated recipient mice
    Morimoto H, Ogonuki N, Matoba S, Tokita S, Kanatsu-Shinohara M, Miyazaki T, Ogura A, Shinohara T.
    Biol Reprod. 2025 Nov 14. doi: 10.1093/biolre/ioaf183

  21. ADAM5 is required for sperm-zona pellucida binding and sperm oviduct migration
    Mashiko D, Tonai S, Ikawa M.
    Biol Reprod. 2025 Nov 20. doi: 10.1093/biolre/ioaf254

  22. A simple, efficient, and scalable method to generate oocyte-like cells in vitro
    Banno A, Mizuno K, Sakamoto M, Komatsubara S, Shirane K, Hayashi K, Hamazaki N, Imami K, Yonemura S, Ishiuchi T.
    Life Science Alliance. 2025 Nov 21. doi: 10.26508/lsa.202503379

  23. Lipid Nanoparticle-mediated mRNA delivery system into preimplantation embryos
    Emori C, Tanaka H, Nakagawa T, Akita H, Ikawa M.
    Biol Reprod. 2025 Nov 27. doi: 10.1093/biolre/ioaf262

  24. Transitioning from human primordial germ cells to embryonic germ cells
    Iwatsuki K, Takashima Y.
    Stem Cell Reports. 2025 Dec 26. doi: 10.1016/j.stemcr.2025.102749

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